Publications

Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain

Nawarathnage S, Tseng YJ, Soleimani S, Smith T, Pedroza Romo MJ, Abiodun WO, Egbert CM, Madhusanka D, Bunn D, Woods B, Tsubaki E, Stewart C, Brown S, Doukov T, Andersen JL, Moody JD.

Structure. 2023 Dec 7;31(12):1589-1603.e6. Epub 2023 Sep 29. PubMed PMID: 37776857; NIHMSID:NIHMS1931618.

Integrating Clinical Cancer and PTM Proteomics Data Identifies a Mechanism of ACK1 Kinase Activation

Balasooriya ER, Madhusanka D, Lopez-Palacios TP, Eastmond RJ, Jayatunge D, Owen JJ, Gashler JS, Egbert CM, Bulathsinghalage C, Liu L, Piccolo SR, Andersen JL.

Mol Cancer Res. 2023 Oct 17;. [Epub ahead of print] PubMed PMID: 37847650; NIHMSID:NIHMS1939797.

Data-Dependent Acquisition with Precursor Coisolation Improves Proteome Coverage and Measurement Throughput for Label-Free Single-Cell Proteomics

Truong T, Webber KGI, Madisyn Johnston S, Boekweg H, Lindgren CM, Liang Y, Nydegger A, Xie X, Tsang TM, Jayatunge DADN, Andersen JL, Payne SH, Kelly RT.

Angew Chem Int Ed Engl. 2023 Aug 21;62(34):e202303415. Epub 2023 Jul 13. PubMed PMID: 37380610; PubMed Central PMCID: PMC10529037.

Kinase regulation by liquid-liquid phase separation

López-Palacios TP, Andersen JL.

Trends Cell Biol. 2023 Aug;33(8):649-666. Epub 2022 Dec 15. Review. PubMed PMID: 36528418; PubMed Central PMCID: PMC10267292.

The Integration of Proteome-Wide PTM Data with Protein Structural and Sequence Features Identifies Phosphorylations that Mediate 14-3-3 Interactions

Egbert CM, Warr LR, Pennington KL, Thornton MM, Vaughan AJ, Ashworth SW, Heaton MJ, English N, Torres MP, Andersen JL.

J Mol Biol. 2023 Jan 30;435(2):167890. Epub 2022 Nov 17. PubMed PMID: 36402225; PubMed Central PMCID: PMC10099770.

Mapping the proximity interactome of ATG9A reveals unexpected dynamics of ULK1 complex proteins

Kannangara AR, Andersen JL.

Autophagy. 2022 Nov;18(11):2754-2755. Epub 2022 Apr 20. PubMed PMID: 35442099; PubMed Central PMCID: PMC9629111.

SGK2, 14-3-3, and HUWE1 Cooperate to Control the Localization, Stability, and Function of the Oncoprotein PTOV1

Pennington KL, McEwan CM, Woods J, Muir CM, Pramoda Sahankumari AG, Eastmond R, Balasooriya ER, Egbert CM, Kaur S, Heaton T, McCormack KK, Piccolo SR, Kurokawa M, Andersen JL.

Mol Cancer Res. 2022 Feb;20(2):231-243. Epub 2021 Oct 15. PubMed PMID: 34654719; PubMed Central PMCID: PMC8816884.

Mechanistic discoveries and simulation-guided assay optimization of portable hormone biosensors with cell-free protein synthesis

Hunt JP, Galiardi J, Free TJ, Yang SO, Poole D, Zhao EL, Andersen JL, Wood DW, Bundy BC.

Biotechnol J. 2022 Feb;17(2):e2100152. Epub 2021 Nov 30. PubMed PMID: 34761537.

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters

Kannangara AR, Poole DM, McEwan CM, Youngs JC, Weerasekara VK, Thornock AM, Lazaro MT, Balasooriya ER, Oh LM, Soderblom EJ, Lee JJ, Simmons DL, Andersen JL.

EMBO Rep. 2021 Oct 5;22(10):e51136. Epub 2021 Aug 9. PubMed PMID: 34369648; PubMed Central PMCID: PMC8490997.

TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

Chan TY, Egbert CM, Maxson JE, Siddiqui A, Larsen LJ, Kohler K, Balasooriya ER, Pennington KL, Tsang TM, Frey M, Soderblom EJ, Geng H, Müschen M, Forostyan TV, Free S, Mercenne G, Banks CJ, Valdoz J, Whatcott CJ, Foulks JM, Bearss DJ, O'Hare T, Huang DCS, Christensen KA, Moody J, Warner SL, Tyner JW, Andersen JL.

Nat Commun. 2021 Sep 9;12(1):5337. PubMed PMID: 34504101; PubMed Central PMCID: PMC8429728.

SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA

Yan D, Franzini A, Pomicter AD, Halverson BJ, Antelope O, Mason CC, Ahmann JM, Senina AV, Vellore NA, Jones CL, Zabriskie MS, Than H, Xiao MJ, van Scoyk A, Patel AB, Clair PM, Heaton WL, Owen SC, Andersen JL, Egbert CM, Reisz JA, D'Alessandro A, Cox JE, Gantz KC, Redwine HM, Iyer SM, Khorashad JS, Rajabi N, Olsen CA, O'Hare T, Deininger MW.

Blood Cancer Discov. 2021 May;2(3):266-287. Epub 2019 Dec 2. PubMed PMID: 34027418; PubMed Central PMCID: PMC8133360.

Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway

Chandrasekharan B, Montllor-Albalate C, Colin AE, Andersen JL, Jang YC, Reddi AR.

Biochem Biophys Res Commun. 2021 Jan 1;534:720-726. Epub 2020 Nov 18. PubMed PMID: 33218686; PubMed Central PMCID: PMC7785591.

Mechanisms of SOD1 regulation by post-translational modifications

Banks CJ, Andersen JL.

Redox Biol. 2019 Sep;26:101270. Epub 2019 Jul 6. Review. PubMed PMID: 31344643; PubMed Central PMCID: PMC6658992.

Proteomic Analysis of Resistance of Gram-Negative Bacteria to Chlorhexidine and Impacts on Susceptibility to Colistin, Antimicrobial Peptides, and Ceragenins

Hashemi MM, Holden BS, Coburn J, Taylor MF, Weber S, Hilton B, Zaugg AL, McEwan C, Carson R, Andersen JL, Price JC, Deng S, Savage PB.

Front Microbiol. 2019;10:210. eCollection 2019. PubMed PMID: 30833936; PubMed Central PMCID: PMC6388577.

Extra-mitochondrial Cu/Zn superoxide dismutase (Sod1) is dispensable for protection against oxidative stress but mediates peroxide signaling in Saccharomyces cerevisiae

Montllor-Albalate C, Colin AE, Chandrasekharan B, Bolaji N, Andersen JL, Wayne Outten F, Reddi AR.

Redox Biol. 2019 Feb;21:101064. Epub 2018 Dec 1. PubMed PMID: 30576923; PubMed Central PMCID: PMC6302037.

The nuclear variant of bone morphogenetic protein 2 (nBMP2) is expressed in macrophages and alters calcium response

Tellez Freitas CM, Burrell HR, Valdoz JC, Hamblin GJ, Raymond CM, Cox TD, Johnson DK, Andersen JL, Weber KS, Bridgewater LC.

Sci Rep. 2019 Jan 30;9(1):934. PubMed PMID: 30700748; PubMed Central PMCID: PMC6353957.

Imbalanced sphingolipid signaling is maintained as a core proponent of a cancerous phenotype in spite of metabolic pressure and epigenetic drift

Speirs MMP, Swensen AC, Chan TY, Jones PM, Holman JC, Harris MB, Maschek JA, Cox JE, Carson RH, Hill JT, Andersen JL, Prince JT, Price JC.

Oncotarget. 2019 Jan 11;10(4):449-479. eCollection 2019 Jan 11. PubMed PMID: 30728898; PubMed Central PMCID: PMC6355186.

The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein-protein interactions

Pennington KL, Chan TY, Torres MP, Andersen JL.

Oncogene. 2018 Oct;37(42):5587-5604. Epub 2018 Jun 18. Review. PubMed PMID: 29915393; PubMed Central PMCID: PMC6193947.

Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration

Banks CJ, Rodriguez NW, Gashler KR, Pandya RR, Mortenson JB, Whited MD, Soderblom EJ, Thompson JW, Moseley MA, Reddi AR, Tessem JS, Torres MP, Bikman BT, Andersen JL.

Mol Cell Biol. 2017 Oct 15;37(20). Print 2017 Oct 15. PubMed PMID: 28739857; PubMed Central PMCID: PMC5615182.

Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket

Mortenson JB, Heppler LN, Banks CJ, Weerasekara VK, Whited MD, Piccolo SR, Johnson WE, Thompson JW, Andersen JL.

J Biol Chem. 2015 May 15;290(20):12487-96. Epub 2015 Mar 13. PubMed PMID: 25770209; PubMed Central PMCID: PMC4432270.

Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9

Weerasekara VK, Panek DJ, Broadbent DG, Mortenson JB, Mathis AD, Logan GN, Prince JT, Thomson DM, Thompson JW, Andersen JL.

Mol Cell Biol. 2014 Dec;34(24):4379-88. Epub 2014 Sep 29. PubMed PMID: 25266655; PubMed Central PMCID: PMC4248729.

Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis

Johnson ES, Lindblom KR, Robeson A, Stevens RD, Ilkayeva OR, Newgard CB, Kornbluth S, Andersen JL.

J Biol Chem. 2013 May 17;288(20):14463-14475. Epub 2013 Apr 3. PubMed PMID: 23553630; PubMed Central PMCID: PMC3656301.

The tangled circuitry of metabolism and apoptosis

Andersen JL, Kornbluth S.

Mol Cell. 2013 Feb 7;49(3):399-410. Review. PubMed PMID: 23395270; PubMed Central PMCID: PMC3801185.

Identification of deacetylase substrates with the biotin switch approach

Thompson JW, Robeson A, Andersen JL.

Methods Mol Biol. 2013;1077:133-48. PubMed PMID: 24014404.

Mcl-1 rescues a glitch in the matrix

Andersen JL, Kornbluth S.

Nat Cell Biol. 2012 May 30;14(6):563-5. PubMed PMID: 22643875.

Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis

Kim J, Parrish AB, Kurokawa M, Matsuura K, Freel CD, Andersen JL, Johnson CE, Kornbluth S.

EMBO J. 2012 Mar 7;31(5):1279-92. Epub 2012 Jan 13. PubMed PMID: 22246185; PubMed Central PMCID: PMC3297998.

A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2

Andersen JL, Thompson JW, Lindblom KR, Johnson ES, Yang CS, Lilley LR, Freel CD, Moseley MA, Kornbluth S.

Mol Cell. 2011 Sep 2;43(5):834-42. PubMed PMID: 21884983; PubMed Central PMCID: PMC3417139.

Meeting the (N-terminal) end with acetylation

Andersen JL, Kornbluth S.

Cell. 2011 Aug 19;146(4):503-5. PubMed PMID: 21854977.

Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2

Andersen JL, Johnson CE, Freel CD, Parrish AB, Day JL, Buchakjian MR, Nutt LK, Thompson JW, Moseley MA, Kornbluth S.

EMBO J. 2009 Oct 21;28(20):3216-27. Epub 2009 Sep 3. PubMed PMID: 19730412; PubMed Central PMCID: PMC2771089.

A cut above the other caspases

Andersen JL, Kornbluth S.

Mol Cell. 2009 Sep 24;35(6):733-4. PubMed PMID: 19782021.

Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2

Nutt LK, Buchakjian MR, Gan E, Darbandi R, Yoon SY, Wu JQ, Miyamoto YJ, Gibbons JA, Andersen JL, Freel CD, Tang W, He C, Kurokawa M, Wang Y, Margolis SS, Fissore RA, Kornbluth S.

Dev Cell. 2009 Jun;16(6):856-66. PubMed PMID: 19531356; PubMed Central PMCID: PMC2698816.

HIV-1 Vpr: mechanisms of G2 arrest and apoptosis

Andersen JL, Le Rouzic E, Planelles V.

Exp Mol Pathol. 2008 Aug;85(1):2-10. Epub 2008 Apr 25. Review. PubMed PMID: 18514189; PubMed Central PMCID: PMC2610539.

HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT

Andersen JL, DeHart JL, Zimmerman ES, Ardon O, Kim B, Jacquot G, Benichou S, Planelles V.

PLoS Pathog. 2006 Dec;2(12):e127. PubMed PMID: 17140287; PubMed Central PMCID: PMC1665652.

Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 Vpr

Ardon O, Zimmerman ES, Andersen JL, DeHart JL, Blackett J, Planelles V.

J Virol. 2006 Apr;80(8):3694-700. PubMed PMID: 16571786; PubMed Central PMCID: PMC1440437.

ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis

Andersen JL, Zimmerman ES, DeHart JL, Murala S, Ardon O, Blackett J, Chen J, Planelles V.

Cell Death Differ. 2005 Apr;12(4):326-34. PubMed PMID: 15650754.

The ataxia telangiectasia-mutated and Rad3-related protein is dispensable for retroviral integration

Dehart JL, Andersen JL, Zimmerman ES, Ardon O, An DS, Blackett J, Kim B, Planelles V.

J Virol. 2005 Feb;79(3):1389-96. PubMed PMID: 15650165; PubMed Central PMCID: PMC544104.

The role of Vpr in HIV-1 pathogenesis

Andersen JL, Planelles V.

Curr HIV Res. 2005 Jan;3(1):43-51. Review. PubMed PMID: 15638722.

Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation

Zimmerman ES, Chen J, Andersen JL, Ardon O, Dehart JL, Blackett J, Choudhary SK, Camerini D, Nghiem P, Planelles V.

Mol Cell Biol. 2004 Nov;24(21):9286-94. PubMed PMID: 15485898; PubMed Central PMCID: PMC522272.

Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain.

Structure (London, England : 1993). . NIHMSID: NIHMS1942398.